Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.

Consensus exists that lipids must play key functions in synaptic activity but precise mechanistic information is limited. Acid sphingomyelinase knockout mice (ASMko) are a suitable model to address the role of sphingolipids in synaptic regulation as they recapitulate a mental retardation syndrome, N...

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Main Authors: Paola G Camoletto, Hugo Vara, Laura Morando, Emma Connell, Fabio P Marletto, Maurizio Giustetto, Marco Sassoè-Pognetto, Paul P Van Veldhoven, Maria Dolores Ledesma
Format: Article
Jezik:English
Izdano: Public Library of Science (PLoS) 2009-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC2668795?pdf=render