Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome

Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome

Abstract Background Nijmegen breakage syndrome is an autosomal recessive disorder characterized by microcephaly, immunodeficiency, hypersensitivity to X-irradiation, and a high predisposition to cancer. Nibrin, the product of the NBN gene, is part of the MRE11/RAD50 (MRN) complex that is involved in...

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Bibliographic Details
Main Authors: Raneem Habib, Heidemarie Neitzel, Aurelie Ernst, John K. L. Wong, Bozenna Goryluk-Kozakiewicz, Antje Gerlach, Ilja Demuth, Karl Sperling, Krystyna Chrzanowska
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cytogenetics
Subjects:
Nijmegen breakage syndrome
Cell line
Unbalanced translocation
Proliferative advantage
Online Access:http://link.springer.com/article/10.1186/s13039-018-0364-6

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http://link.springer.com/article/10.1186/s13039-018-0364-6

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