Conditional Deletion of Activating Rearranged During Transfection Receptor Tyrosine Kinase Leads to Impairment of Photoreceptor Ribbon Synapses and Disrupted Visual Function in Mice

Conditional Deletion of Activating Rearranged During Transfection Receptor Tyrosine Kinase Leads to Impairment of Photoreceptor Ribbon Synapses and Disrupted Visual Function in Mice

Purpose: The rearranged during transfection (RET) receptor tyrosine kinase plays a key role in transducing signals related to cell growth and differentiation. Ret mutant mice show abnormal retinal activity and abnormal levels and morphology of bipolar cells, yet die on the 21st day after birth as a...

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Bibliographic Details
Main Authors: Wei-Hao Peng, Meng-Lin Liao, Wan-Chun Huang, Pei-Kang Liu, Sarah R. Levi, Yun-Ju Tseng, Chia-Ying Lee, Lung-Kun Yeh, Kuan-Jen Chen, Chung-Liang Chien, Nan-Kai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Neuroscience
Subjects:
GDNF family of ligands (GFL)
rearranged during transfection (RET)
mouse retina
ribbon synapses
Cre-loxP knockout mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.728905/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.728905/full

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