ALK Gene Rearrangements in Lung Adenocarcinomas: Concordance of Immunohistochemistry, Fluorescence In Situ Hybridization, RNA In Situ Hybridization, and RNA Next-Generation Sequencing Testing

ALK Gene Rearrangements in Lung Adenocarcinomas: Concordance of Immunohistochemistry, Fluorescence In Situ Hybridization, RNA In Situ Hybridization, and RNA Next-Generation Sequencing Testing

Introduction: The 2018 updated molecular testing guidelines for patients with advanced lung cancer incorporated ALK immunohistochemistry (IHC) analysis as an equivalent to fluorescence in situ hybridization (FISH) method recommended in 2013. Nevertheless, no specific recommendation for alternative m...

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Bibliographic Details
Main Authors: Carleigh R. Canterbury, DDS, Helen Fernandes, PhD, John P. Crapanzano, MD, Vundavalli V. Murty, PhD, Mahesh M. Mansukhani, MD, Catherine A. Shu, MD, Matthias Szabolcs, MD, Anjali Saqi, MD, MBA
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:JTO Clinical and Research Reports
Subjects:
ALK
Fluorescent in situ hybridization (FISH)
Next-generation sequencing (NGS)
RNA in situ hybridization (RNA ISH)
Archer
Anchored multiplex
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364321000825

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http://www.sciencedirect.com/science/article/pii/S2666364321000825

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