Changes in Frequency and Activation Status of Major CD4+ T-Cell Subsets after Initiation of Immunosuppressive Therapy in a Patient with New Diagnosis Childhood-Onset Systemic Lupus Erythematosus

BackgroundSeveral studies suggest that defects of regulatory T-cells (Tregs) and impaired cellular immunity are secondary to an imbalance between auto-aggressive T-cells and Tregs in lupus patients. Discrepancies in Tregs and effector T-cells (Teff) in active lupus patients are shown to be restored...

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Bibliographic Details
Main Authors:	Saimun Singla, Scott E. Wenderfer, Eyal Muscal, Anna Carmela P. Sagcal-Gironella, Jordan S. Orange, George Makedonas
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-05-01
Series:	Frontiers in Pediatrics
Subjects:	T regulatory cells T effector cells childhood-onset systemic lupus erythematosus T-cell exhaustion PD-1
Online Access:	http://journal.frontiersin.org/article/10.3389/fped.2017.00104/full

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http://journal.frontiersin.org/article/10.3389/fped.2017.00104/full

Changes in Frequency and Activation Status of Major CD4+ T-Cell Subsets after Initiation of Immunosuppressive Therapy in a Patient with New Diagnosis Childhood-Onset Systemic Lupus Erythematosus

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