Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer formation

Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer formation

The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main pharmacological targets of somatostatin analogs (SSAs), than...

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Bibliographic Details
Main Authors: Donatella Treppiedi, Giusy Marra, Genesio Di Muro, Rosa Catalano, Federica Mangili, Emanuela Esposito, Davide Calebiro, Maura Arosio, Erika Peverelli, Giovanna Mantovani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
GPCR dimerization
in situ PLA
somatostatin analogs
FLNA
SST2
SST5
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.892668/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.892668/full

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