Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model

Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model

Background Deep vein thrombosis (DVT) is the primary cause of pulmonary embolism and the third most life‐threatening cardiovascular disease in North America. Post‐DVT anticoagulants, such as warfarin, heparin, and direct oral anticoagulants, reduce the incidence of subsequent venous thrombi. However...

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Bibliographic Details
Main Authors: Catherine Lapointe, Laurence Vincent, Hugo Giguère, Mannix Auger‐Messier, Adel Schwertani, Denan Jin, Shinji Takai, Gunnar Pejler, Martin G. Sirois, Hanna Tinel, Stefan Heitmeier, Pedro D'Orléans‐Juste
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
chymase
deep vein thrombosis
mouse mast cell protease‐4 knockout
mouse
plasmin
TY‐51469
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.028056

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.122.028056

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