Effects of endothelial nitric oxide synthase on mouse arteriovenous fistula hemodynamics

Abstract Newly created arteriovenous fistulas (AVFs) often fail to mature for dialysis use due to disturbed blood flow at and near the AVF anastomosis. The disturbed flow inhibits the endothelial nitric oxide synthase (NOS3) pathway, thus decreasing the production of nitric oxide, a vasodilator. Pre...

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Bibliographic Details
Main Authors: Shelly Baltazar, Hannah Northrup, Joshua Chang, Maheshika Somarathna, Tatyana Isayeva Waldrop, Timmy Lee, Yan-Ting Shiu
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-49573-5