Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Chimeric antigen receptor (CAR)-modified natural killer (NK) cell therapy represents a kind of promising anti-cancer treatment because CAR renders NK cells activation and recognition specificity toward tumor cells. An immune checkpoint molecule, B7-H3, plays an inhibitory role in modulation of NK ce...

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Bibliographic Details
Main Authors: Shuo Yang, Bihui Cao, Guangyu Zhou, Lipeng Zhu, Lu Wang, Li Zhang, Hang Fai Kwok, Zhenfeng Zhang, Qi Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
B7-H3
chimeric antigen receptor
NK-92
immune checkpoint
natural killer cell
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01089/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01089/full

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