Potentiating effect of reovirus on immune checkpoint inhibition in microsatellite stable colorectal cancer

Potentiating effect of reovirus on immune checkpoint inhibition in microsatellite stable colorectal cancer

The majority of colorectal cancers (CRCs) are microsatellite stable (MSS) and resistant to immunotherapy. The current study explores the possibility of using oncolytic reovirus to sensitize MSS CRC to immune checkpoint inhibition. While reovirus reduced metabolic activity among KRASMut cells, microa...

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Bibliographic Details
Main Authors: Titto Augustine, Peter John, Tyler Friedman, Jeeshan Jiffry, Hillary Guzik, Rifat Mannan, Riya Gupta, Catherine Delano, John M. Mariadason, Xingxing Zang, Radhashree Maitra, Sanjay Goel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
translational
combinatorial therapy
reovirus
anti-PD-1
immune checkpoint
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1018767/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1018767/full

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