Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model

Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model

The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC), but it is largely unknown how the microbiota affects the pathogenesis of mismatch-repair-deficient CRC in the context of Lynch syndrome. In a mouse model for Lynch syndrome, we found a nearly complete loss of in...

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Bibliographic Details
Main Authors: Wietske Pieters, Floor Hugenholtz, Kevin Kos, Maxime Cammeraat, Teddy C. Moliej, Daphne Kaldenbach, Sjoerd Klarenbeek, Mark Davids, Lisa Drost, Charlotte de Konink, Elly Delzenne-Goette, Karin E. de Visser, Hein te Riele
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
lynch syndrome
mismatch repair
microbiota
mutagenesis
colorectal cancer
Online Access:http://dx.doi.org/10.1080/19490976.2022.2035660

Internet

http://dx.doi.org/10.1080/19490976.2022.2035660

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