Pharmacological Antagonism of the Kisspeptin-Neurokinin System Improved Adverse Metabolic Traits in a PCOS Mouse Model

Pharmacological Antagonism of the Kisspeptin-Neurokinin System Improved Adverse Metabolic Traits in a PCOS Mouse Model

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition affecting up to 20% of reproductively aged women worldwide. Owing to an ambiguous etiology and complicated pathophysiology, current PCOS treatments remain purely symptomatic. Aberrations in androgen receptor driven n...

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Bibliographic Details
Main Authors: Irene E. SUCQUART, Ruchi NAGARKAR, Melissa C. EDWARDS, Valentina RODRIGUEZ PARIS, Ali AFLATOUNIAN, Michael J. BERTOLDO, Rebecca E. CAMPBELL, Denovan P. BEGG, David J. HANDELSMAN, Vasantha PADMANABHAN, Richard A. ANDERSON, Robert B. GILCHRIST, Kirsty A. WALTERS
Format: Article
Language:English
Published: World Scientific Publishing 2022-09-01
Series:Fertility & Reproduction
Online Access:https://www.worldscientific.com/doi/10.1142/S2661318222740723

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https://www.worldscientific.com/doi/10.1142/S2661318222740723

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