Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain

Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain

Both opioids and cannabinoids have well-known antinociceptive effects in different animal models of chronic pain. However, unwanted side effects limit their use. The aim of this study is to evaluate the antinociceptive effect of combining synthetic cannabinoids with subtherapeutic doses of opioids,...

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Bibliographic Details
Main Authors: Mohammad Alsalem, Ahmad Altarifi, Mansour Haddad, Belal Azab, Heba Kalbouneh, Amer Imraish, Tareq Saleh, Khalid El-Salem
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Brain Sciences
Subjects:
chronic pain
Complete Freund’s Adjuvant (CFA)
streptozotocin (STZ)
von Frey filament test
morphine
tramadol
Online Access:https://www.mdpi.com/2076-3425/10/8/523

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https://www.mdpi.com/2076-3425/10/8/523

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