Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation—A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation—A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Hypercoagulation and endothelial dysfunction play central roles in severe forms of COVID-19 infections, but the molecular mechanisms involved are unclear. Increased plasma levels of the inflammatory cytokine and TIE2 receptor antagonist Angiopoietin-2 were reported in severely ill COVID-19 patients....

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Bibliographic Details
Main Authors: Michael Hultström, Karin Fromell, Anders Larsson, Barbro Persson, Bo Nilsson, Susan E. Quaggin, Christer Betsholtz, Robert Frithiof, Miklos Lipcsey, Marie Jeansson
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
Subjects:
COVID-19
hypercoagulation
thrombomodulin
Angiopoietin-2
endothelial dysfunction
Online Access:https://www.mdpi.com/2227-9059/10/6/1333

Internet

https://www.mdpi.com/2227-9059/10/6/1333

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