Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis

Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis

Summary: The human brain is populated by perivascular T cells with a tissue-resident memory T (TRM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions. We investigated the transcriptional and functional profile of freshly isolated T cells from white and gray matter. RNA sequenci...

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Bibliographic Details
Main Authors: Cheng-Chih Hsiao, Hendrik J. Engelenburg, Aldo Jongejan, Jing Zhu, Baohong Zhang, Michael Mingueneau, Perry D. Moerland, Inge Huitinga, Joost Smolders, Jörg Hamann
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Neuroscience
Molecular neuroscience
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222020582

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http://www.sciencedirect.com/science/article/pii/S2589004222020582

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