FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway

FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway

Abstract Premature ovarian failure (POF) is a devastating condition for women under 40 years old. Chemotherapy, especially the use of cisplatin, has been demonstrated to promote the apoptosis of granulosa cells in primary and secondary follicles, leading to POF. Our previous studies demonstrated tha...

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Bibliographic Details
Main Authors: Rongli Wang, Feiyan Cheng, Xinyuan Yang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Ovarian Research
Subjects:
Fat mass- and obesity-associated
Hippo/YAP1
Granulosa
Apoptosis
Premature ovarian failure
Online Access:https://doi.org/10.1186/s13048-024-01385-5

Internet

https://doi.org/10.1186/s13048-024-01385-5

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