Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling

Purpose: The incidence of uric acid (UA)-induced kidney injury is increasing owing to the high incidence of hyperuricemia in recent years. The flower of Abelmoschus manihot (Linneus) Medik is a traditional Chinese medicinal herb widely used in the treatment of some kidney diseases. In our previous s...

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Bibliographic Details
Main Authors: Zhihui Ding, Jing Zhao, Xufang Wang, Wei Li, Chong Chen, Chen Yong, Yiye Zhu, Fang Tian, Li Liu, Manshu Yu, Enchao Zhou, Liubao Gu, Chunlei Yao, Kun Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
pyroptosis
uric acid
caspase-8
caspase-3
NLRP3
GSDME
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.907980/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.907980/full

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