Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores
Abstract 5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many conventional genetic techniques and is thus challenging to probe. Here, we...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/srep29565 |