TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

Sepsis is associated with profound immune dysregulation that increases the risk for life-threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming due to yet unknown changes during differentiation in the bone marrow (BM). In parallel, lymphopenia and exhaustion of T ly...

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Bibliographic Details
Main Authors: Anne-Charlotte Antoni, Ekaterina Pylaeva, Bettina Budeus, Jadwiga Jablonska, Ludger Klein-Hitpaß, Marcel Dudda, Stefanie B. Flohé
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
differentiation
sepsis
bone marrow
T cells
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.945409/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.945409/full

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