Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation.

Regulator of G protein signaling 10 (RGS10), a GTPase accelerating protein (GAP) for G alpha subunits, is a negative regulator of NF-κB in microglia. Here, we investigated the role of RGS10 in macrophages, a closely related myeloid-derived cell type. Features of classical versus alternative activati...

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Bibliographic Details
Main Authors: Jae-Kyung Lee, Jaegwon Chung, George T Kannarkat, Malú G Tansey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3836764?pdf=render