NAADP-Evoked Ca<sup>2+</sup> Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

NAADP-Evoked Ca<sup>2+</sup> Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

Huntington’s disease (HD) is a progressive neurodegenerative disease characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of the CAG trinucleotide, leading to abnormal long repeats of polyglutamine (poly-Q) in the N-terminal region of the huntingtin, which form abnorm...

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Bibliographic Details
Main Authors: Cássia Arruda de Souza Pereira, Natalia de Castro Medaglia, Rodrigo Portes Ureshino, Claudia Bincoletto, Manuela Antonioli, Gian Maria Fimia, Mauro Piacentini, Gustavo José da Silva Pereira, Adolfo Garcia Erustes, Soraya Soubhi Smaili
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
Huntington’s disease
lysosome
NAADP
two-pore channels
Online Access:https://www.mdpi.com/1422-0067/24/6/5593

Internet

https://www.mdpi.com/1422-0067/24/6/5593

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