RP-HPLC method development and validation for bedaquiline fumarate to evaluate its forced degradation behaviour and stability in official dissolution media

RP-HPLC method development and validation for bedaquiline fumarate to evaluate its forced degradation behaviour and stability in official dissolution media

Abstract Background A simple, rapid and accurate reverse phase RP-HPLC method for the validation of antitubercular drug bedaquiline fumarate (BQF) was developed. The stability and forced degradation behaviour of bedaquiline fumarate (BQF) in official dissolution media (0.01 N HCl) and methanol were...

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Bibliographic Details
Main Authors: Vishwas Pardhi, Geetanjali Pant, S. J. S. Flora
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Antitubercular
Bedaquiline fumarate
Accuracy
Precision
Stability
Hydrolytic degradation
Online Access:http://link.springer.com/article/10.1186/s43094-020-00061-x

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http://link.springer.com/article/10.1186/s43094-020-00061-x

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