Development, validation, and application of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the estimation of Ropanicant in human plasma and urine

Development, validation, and application of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the estimation of Ropanicant in human plasma and urine

SUVN-911 (Ropanicant) is a novel alpha-4 beta-2 nicotinic acetylcholine receptor (α4β2 nAChR) antagonist being developed for the treatment of major depressive disorders (MDD). An Ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated fo...

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Bibliographic Details
Main Authors: Ramakrishna Nirogi, Ilayaraja Kalaikadhiban, Lakshmi Prasanna Rayapati, Hanumanth Rao Pantangi, Prathyusha Chunduru, Satish Jetta, Avinash Jubre, Abdul Rasheed Mohammed
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Chromatography Open
Subjects:
SUVN-911
Polar basic compound
Reverse phase chromatography
UHPLC-MS/MS
Major depressive disorders
Bioanalytical method
Online Access:http://www.sciencedirect.com/science/article/pii/S2772391722000433

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http://www.sciencedirect.com/science/article/pii/S2772391722000433

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