Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients.

PURPOSE:To test the hypothesis that autophagy dysfunction is involved in exfoliation syndrome (XFS), a systemic disorder of extracellular elastic matrices that causes a distinct form of human glaucoma. METHODS:Fibroblasts derived from tenon tissue discards (TFs) from filtration surgery to relieve in...

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Bibliographic Details
Main Authors: Andrew Want, Stephanie R Gillespie, Zheng Wang, Ronald Gordon, Carlo Iomini, Robert Ritch, J Mario Wolosin, Audrey M Bernstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4938507?pdf=render