Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation

Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation

Abstract Rheumatoid arthritis (RA) is characterized by bone destruction in the afflicted joints, and during the process of bone destruction, osteoclasts play a crucial role. Tanshinone IIA (Tan IIA) has shown anti-inflammatory effects in RA. However, the exact molecular mechanisms by which it delays...

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Bibliographic Details
Main Authors: Qiuwei Peng, Jian Wang, Man Han, Minghong Zhao, Kesong Li, Tianming Lu, Qiuyan Guo, Quan Jiang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Chinese Medicine
Subjects:
Tanshinone IIA
Rheumatoid arthritis
Osteoclast
Lactate dehydrogenase
Reactive oxygen species
Online Access:https://doi.org/10.1186/s13020-023-00765-1

Internet

https://doi.org/10.1186/s13020-023-00765-1

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