Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

Niemann-Pick type C (NPC) disease, sometimes called childhood Alzheimer’s, is a rare neurovisceral lipid storage disease with progressive neurodegeneration leading to premature death. The disease is caused by loss-of-function mutations in the Npc1 or Npc2 gene which both result into lipid accumulati...

Full description

Bibliographic Details
Main Authors: Lien Van Hoecke, Caroline Van Cauwenberghe, Kristina Dominko, Griet Van Imschoot, Elien Van Wonterghem, Jonas Castelein, Junhua Xie, Wouter Claeys, Charysse Vandendriessche, Anna Kremer, Peter Borghgraef, Riet De Rycke, Silva Hecimovic, Roosmarijn E. Vandenbroucke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Niemann-Pick type C disease
choroid plexus
extracellular vesicles
blood-CSF-barrier
autophagosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.757482/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.757482/full

Similar Items