Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity

Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity

Senescence is considered to be a cardinal player in several chronic inflammatory and metabolic pathologies. The two dominant mechanisms of senescence include replicative senescence, predominantly depending on age-induced telomere shortening, and stress-induced senescence, triggered by external or in...

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Bibliographic Details
Main Authors: Ioannis I. Moustakas, Angeliki Katsarou, Aigli-Ioanna Legaki, Iryna Pyrina, Konstantinos Ntostoglou, Alkistis-Maria Papatheodoridi, Bettina Gercken, Ioannis S. Pateras, Vassilis G. Gorgoulis, Michael Koutsilieris, Triantafyllos Chavakis, Antonios Chatzigeorgiou
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
NAFLD
age
hepatocyte
replicative senescence
stress-induced senescence
obesity
Online Access:https://www.mdpi.com/1422-0067/22/7/3446

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https://www.mdpi.com/1422-0067/22/7/3446

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