IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

IS26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

ABSTRACT Multidrug-resistant Gram-negative carriers of Klebsiella pneumoniae carbapenemases (KPCs) often subvert antibiotic therapy due to inadequate sensitivity in laboratory detection. Although unstable gene amplification has been recognized to crucially contribute to underestimation or misestimat...

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Bibliographic Details
Main Authors: Da-Wei Wei, Nai-Kei Wong, Yuqin Song, Gang Zhang, Chao Wang, Juan Li, Jie Feng
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
antimicrobial resistance
Klebsiella pneumoniae carbapenemase (KPC)
insertion sequence IS26
gene amplification
genomic plasticity
genetic rearrangement
Online Access:https://journals.asm.org/doi/10.1128/mbio.03340-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03340-21

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