Astragaloside-IV Protects Against Heat-induced Apoptosis by Inhibiting Excessive Activation of Mitochondrial Ca2+ Uniporter

Astragaloside-IV Protects Against Heat-induced Apoptosis by Inhibiting Excessive Activation of Mitochondrial Ca2+ Uniporter

Background: Heat causes airway damage during inhalation injury because of bronchial epithelial cell damage. Accumulating evidence shows that mitochondrial uniporter (MCU) is involved in cell damage. We investigated the MCU activity after heat treatment and assessed whether Astragaloside-IV (AS-IV) s...

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Bibliographic Details
Main Authors: Zhiwei Dong, Chen Zhang, Yajie Chen, Yu Chen, Zhiqiang Yuan, Yizhi Peng, Tongtong Cao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Astragaloside-IV
Heat injury
MCU
Ca2+ overload
ROS
Apoptosis
Online Access:http://www.karger.com/Article/FullText/477595

Internet

http://www.karger.com/Article/FullText/477595

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