Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polym...

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Bibliographic Details
Main Authors: Csaba Hegedűs, László Virág
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Poly(ADP-ribosyl)ation
PARP1
Oxidative stress
Cell death
Necroptosis
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000937

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http://www.sciencedirect.com/science/article/pii/S2213231714000937

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