Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling

Background: Peritoneal fibrosis (PF) is an intractable complication in patients on long-term peritoneal dialysis (PD). Transforming growth factor-β (TGF-β) is a key pro-fibrogenic factor involved in PD-associated PF, and endoglin, as a coreceptor for TGF-β, plays a role in balancing the TGF-β signal...

Full description

Bibliographic Details
Main Authors: Qian Huang, Rui Xiao, Jing Lu, Yao Zhang, Liang Xu, Jie Gao, Jing Sun, Haiping Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
endoglin
peritoneal fibrosis
angiogenesis
EMT
TGF-β/ALK/Smads
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.973182/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.973182/full

Similar Items