Robust expansion and functional maturation of human hepatoblasts by chemical strategy

Robust expansion and functional maturation of human hepatoblasts by chemical strategy

Abstract Background Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepatic cells remain challenging, especially in terms of step-wise efficacy...

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Bibliographic Details
Main Authors: Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao, Yin-xiong Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Stem Cell Research & Therapy
Subjects:
Hepatoblast expansion
Hepatic maturation
Stemness maintenance
Small molecules
Chemical cocktail
Online Access:https://doi.org/10.1186/s13287-021-02233-9

Internet

https://doi.org/10.1186/s13287-021-02233-9

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