Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

The clinical success of PD-1/PD-L1 immune checkpoint targeting antibodies in cancer is followed by efforts to develop small molecule inhibitors with better penetration into solid tumors and more favorable pharmacokinetics. Here we report the crystal structure of a macrocyclic peptide inhibitor (pept...

Полное описание

Библиографические подробности
Главные авторы: Edyta Zyla, Bogdan Musielak, Tad A. Holak, Grzegorz Dubin
Формат: Статья
Язык:English
Опубликовано: MDPI AG 2021-08-01
Серии:Molecules
Предметы:
Online-ссылка:https://www.mdpi.com/1420-3049/26/16/4848