Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis
The clinical success of PD-1/PD-L1 immune checkpoint targeting antibodies in cancer is followed by efforts to develop small molecule inhibitors with better penetration into solid tumors and more favorable pharmacokinetics. Here we report the crystal structure of a macrocyclic peptide inhibitor (pept...
Главные авторы: | , , , |
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Формат: | Статья |
Язык: | English |
Опубликовано: |
MDPI AG
2021-08-01
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Серии: | Molecules |
Предметы: | |
Online-ссылка: | https://www.mdpi.com/1420-3049/26/16/4848 |