Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

The clinical success of PD-1/PD-L1 immune checkpoint targeting antibodies in cancer is followed by efforts to develop small molecule inhibitors with better penetration into solid tumors and more favorable pharmacokinetics. Here we report the crystal structure of a macrocyclic peptide inhibitor (pept...

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Bibliographic Details
Main Authors: Edyta Zyla, Bogdan Musielak, Tad A. Holak, Grzegorz Dubin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
immunotherapy
immune checkpoint
PD-L1
PD-1
macrocyclic peptides
Online Access:https://www.mdpi.com/1420-3049/26/16/4848

Internet

https://www.mdpi.com/1420-3049/26/16/4848

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