The Drug Excipient Cyclodextrin Interacts With -Luciferin and Interferes With Bioluminescence Imaging

Cyclodextrins are well-characterized, barrel-shaped molecules that can solubilize organic small molecules in aqueous solution via host–guest interactions. As such, cyclodextrins are used as excipients for experimental therapeutics in vivo. We observed unanticipated modifications to bioluminescence i...

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Bibliographic Details
Main Authors: Jeyan S. Kumar MSc, Lisa M. Miller Jenkins PhD, Michael M. Gottesman MD, Matthew D. Hall PhD
Format: Article
Language:English
Published: SAGE Publications 2016-01-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1177/1536012115625225