Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells

Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells

Tissue-resident memory T cells (TRM) are critical to host defense at mucosal tissue sites. However, the parenteral route of immunization as the most commonly used immunization route in practice is not effective in inducing mucosal TRM cells particularly in the lung. While various respiratory mucosal...

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Bibliographic Details
Main Authors: Siamak Haddadi, Maryam Vaseghi-Shanjani, Yushi Yao, Sam Afkhami, Michael R. D'Agostino, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
vaccine
parenteral immunization
viral vector
prime-pull
lung
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02075/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02075/full

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