Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy

Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy

Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia, causing iron accumulation, neuroinflammation,...

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Bibliographic Details
Main Authors: José A. Fernández-Albarral, Elena Salobrar-García, José A. Matamoros, Cristina Fernández-Mendívil, Eric del Sastre, Lejing Chen, Rosa de Hoz, Inés López-Cuenca, Lidia Sánchez-Puebla, José M. Ramírez, Juan J. Salazar, Manuela G. Lopez, Ana I. Ramírez
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
tauopathies
heme oxygenase 1 (HO-1)
retina
microglia
macroglia
neuroinflammation
Online Access:https://www.mdpi.com/2076-3921/11/11/2151

Internet

https://www.mdpi.com/2076-3921/11/11/2151

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