Cur@SF NPs alleviate Friedreich’s ataxia in a mouse model through synergistic iron chelation and antioxidation

Cur@SF NPs alleviate Friedreich’s ataxia in a mouse model through synergistic iron chelation and antioxidation

Abstract Abnormal iron metabolism, mitochondrial dysfunction and the derived oxidative damage are the main pathogeneses of Friedrich's ataxia (FRDA), a single-gene inherited recessive neurodegenerative disease characterized by progressive cerebellar and sensory ataxia. This disease is caused by...

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Bibliographic Details
Main Authors: Li Xu, Zichen Sun, Zhiyao Xing, Yutong Liu, Hongting Zhao, Zhongmin Tang, Yu Luo, Shuangying Hao, Kuanyu Li
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
Curcumin
Silk fibroin
Drug delivery
FRDA
Mitochondrial function
Online Access:https://doi.org/10.1186/s12951-022-01333-9

Internet

https://doi.org/10.1186/s12951-022-01333-9

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