Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer

Germline ATM Mutations Detected by Somatic DNA Sequencing in Lethal Prostate Cancer

Background: Germline mutations in the ataxia telangiectasia mutated (ATM) gene occur in 0.5–1% of the overall population and are associated with tumour predisposition. The clinical and pathological features of ATM-mutated prostate cancer (PC) are poorly defined but have been associated with lethal P...

Full description

Bibliographic Details
Main Authors: Rafael Grochot, Suzanne Carreira, Susana Miranda, Ines Figueiredo, Claudia Bertan, Jan Rekowski, Wei Yuan, Ana Ferreira, Ruth Riisnaes, Antje Neeb, Bora Gurel, Maria de Los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Daniel Westaby, Joaquin Mateo, Adam Sharp, Terri P. McVeigh, Johann De Bono
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:European Urology Open Science
Subjects:
Prostate cancer
ATM
DNA damage response
Synthetic lethality
PARP inhibition
ATR inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168323001933

Internet

http://www.sciencedirect.com/science/article/pii/S2666168323001933

Similar Items