Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

Summary: N6-methyladenosine (m6A) is emerging as a vital factor regulating neural differentiation. Here, we report that deficiency of Arhgef2, a novel cause of a neurodevelopmental disorder we identified recently, impairs neurogenesis, neurite outgrowth, and synaptic formation by regulating m6A meth...

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Bibliographic Details
Main Authors: Pei Zhou, Yifei Qi, Xiang Fang, Miaomiao Yang, Shuxin Zheng, Caihua Liao, Fengying Qin, Lili Liu, Hong Li, Yan Li, Ethiraj Ravindran, Chuanbo Sun, Xinshu Wei, Wen Wang, Liang Fang, Dingding Han, Changgeng Peng, Wei Chen, Na Li, Angela M. Kaindl, Hao Hu
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Molecular neuroscience
Developmental neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006131

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http://www.sciencedirect.com/science/article/pii/S2589004221006131

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