5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines

5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines

Vincristine is the drug of choice for Hodgkin’s lymphoma, acute lymphoblastic leukemia, and non-Hodgkin lymphoma. Despite its significant anticancer effects, it causes dose-dependent neuropathy, leading to compulsive dose reduction. The available drugs used for vincristine-induced neuropathic pain (...

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Bibliographic Details
Main Authors: Muhammad Usman, Hurmat Malik, Ahmed Tokhi, Mehreen Arif, Zilli Huma, Khalid Rauf, Robert D. E. Sewell
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
vincristine induced neuropathic pain
5,7-Dimethoxycoumarin
monoamines in brain tissues
behavioral profiling
5HT3 receptors
TNF-α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1213763/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1213763/full

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