5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines

5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines

Vincristine is the drug of choice for Hodgkin’s lymphoma, acute lymphoblastic leukemia, and non-Hodgkin lymphoma. Despite its significant anticancer effects, it causes dose-dependent neuropathy, leading to compulsive dose reduction. The available drugs used for vincristine-induced neuropathic pain (...

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Bibliographic Details
Main Authors:	Muhammad Usman, Hurmat Malik, Ahmed Tokhi, Mehreen Arif, Zilli Huma, Khalid Rauf, Robert D. E. Sewell
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Series:	Frontiers in Pharmacology
Subjects:	vincristine induced neuropathic pain 5,7-Dimethoxycoumarin monoamines in brain tissues behavioral profiling 5HT3 receptors TNF-α
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1213763/full

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