CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide

CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide

Chemotherapy resistant leukemic stem cells (LSCs) are being targeted as a modern therapeutic approach to prevent disease relapse. LSCs isolated from methotrexate resistant side population (SP) of leukemic cell lines HL60 and MOLT4 exhibited high levels of CD25 and TRAIL R2/DR5 which are potential ta...

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Bibliographic Details
Main Authors: Jayaprakasam Madhumathi, Surapally Sridevi, Rama Shanker Verma
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Stem Cell Research
Subjects:
Leukemic stem cells
Immunotoxin
DR5 receptor
Drug resistance
TRAIL
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117300016

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http://www.sciencedirect.com/science/article/pii/S1873506117300016

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