Intranasal vaccination with an engineered influenza virus expressing the receptor binding subdomain of botulinum neurotoxin provides protective immunity against botulism and influenza

Intranasal vaccination with an engineered influenza virus expressing the receptor binding subdomain of botulinum neurotoxin provides protective immunity against botulism and influenza

Influenza virus is a negative, segmented RNA virus without DNA intermediate. This makes it safer as a vaccine delivery vector than most DNA viruses that have potential to integrate their genetic elements into host genomes. In this study, we developed a universal influenza viral vector, expressing th...

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Bibliographic Details
Main Authors: Junwei eLi, Diana eDiaz-Arévalo, Yanping eChen, Mingtao eZeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
Botulinum Neurotoxin
influenza
protective immunity
Intranasal vaccination
recombinant influenza vector
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00170/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00170/full

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