Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle

Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle

Myostatin (<i>Mstn</i>) is a major negative regulator of skeletal muscle mass and initiates multiple metabolic changes. The deletion of the <i>Mstn</i> gene in mice leads to reduced mitochondrial functions. However, the underlying regulatory mechanisms remain unclear. In this...

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Bibliographic Details
Main Authors: Mingjuan Gu, Zhuying Wei, Xueqiao Wang, Yang Gao, Dong Wang, Xuefei Liu, Chunling Bai, Guanghua Su, Lei Yang, Guangpeng Li
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
myostatin
CRISPR/Cas9
knockout
mitochondrial
skeletal muscle
AMPK/SIRT1/PGC-1α
Online Access:https://www.mdpi.com/1422-0067/23/22/13703

Internet

https://www.mdpi.com/1422-0067/23/22/13703

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