Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Abstract Background Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN, in DS-associated transcriptional regulation and phenotypic modulation....

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Bibliographic Details
Main Authors: Zhenglong Guo, Yongchang Zhu, Hai Xiao, Ranran Dai, Wenke Yang, Wei Xue, Xueying Zhang, Bingtao Hao, Shixiu Liao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Biological Research
Subjects:
Down syndrome
Amniocytes
ATAC-seq and RNA-seq
I-IFN
MX1
AP-1
Online Access:https://doi.org/10.1186/s40659-023-00474-x

Internet

https://doi.org/10.1186/s40659-023-00474-x

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