Detecting fa leptin receptor mutation in Zucker rats with tetra-primer amplification-refractory mutation system (ARMS)-PCR

Detecting fa leptin receptor mutation in Zucker rats with tetra-primer amplification-refractory mutation system (ARMS)-PCR

Due to the genetic mutation (fa) in the gene encoding for leptin receptor, homozygous Zucker rats (fa−/−) develop excessive adiposity and become an experimental animal model in obesity and metabolic-related diseases research. Based on tetra-primer amplification refractory mutation system-polymerase...

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Bibliographic Details
Main Authors: Xinyun Xu, Xinge Hu, Guodong Ma, Tiannan Wang, Jayne Wu, Xiaojuan Zhu, Guoxun Chen, Ling Zhao, Jiangang Chen
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
fa mutation
Leptin receptor
Tetra-primer amplification-refractory mutation system (ARMS)
Zucker rats
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402307367X

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http://www.sciencedirect.com/science/article/pii/S240584402307367X

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