Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels.

Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels.

Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons. However, several studies have shown that NMD also targets physiological transcripts that encode full-length proteins, modulating t...

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Bibliographic Details
Main Authors: Rute Martins, Daniela Proença, Bruno Silva, Cristina Barbosa, Ana Luísa Silva, Paula Faustino, Luísa Romão
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3329446?pdf=render

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http://europepmc.org/articles/PMC3329446?pdf=render

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