A functional polymorphism at the miR-25-3p binding site in the 3′-untranslated region of the S1PR1 gene decreases the risk of osteoporosis in Chinese postmenopausal women

A functional polymorphism at the miR-25-3p binding site in the 3′-untranslated region of the S1PR1 gene decreases the risk of osteoporosis in Chinese postmenopausal women

The low bone mineral density due to abnormally activated osteoclasts can induce bone disorders such as osteopenia and osteoporosis. MiR-25-3p modulates sphingosine-1-phosphate receptor 1 (S1PR1) expression to enhance osteoclast motivation. The association between miR-25 rs41274221 polymorphism and o...

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Bibliographic Details
Main Authors: Haoyu Yang, Chenwei Xiong, Zhentang Yu, Zhicheng Yang, Yi Zhang, Junjie Zhang, Yong Huang, Nanwei Xu, Xindie Zhou, Mengqing Jiang, Zhonghua Xu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Arabian Journal of Chemistry
Subjects:
MiR-25-3p
S1PR1
Osteoporosis
Osteoclast
rs41274221
Polymorphism
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223003507

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http://www.sciencedirect.com/science/article/pii/S1878535223003507

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