Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents

Inspired by the potent inhibition activity of the c-Met (mesenchymal−epithelial transition factor) inhibitor Tepotinib, a series of new Tepotinib derivatives were synthesized and evaluated for their ability to act as antiproliferative agents to find the leading compounds with good activity...

Full description

Bibliographic Details
Main Authors: Niu-niu Zhang, Bai-jiao An, Yan Zhou, Xing-shu Li, Ming Yan
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/24/6/1173