Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels

Abstract A hexanucleotide repeat expansion in a noncoding region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Reduction of select or total C9orf72 transcript and protein levels is observed in postmortem C9-ALS/FTD tissue, and l...

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Bibliographic Details
Main Authors: Shangxi Xiao, Paul M. McKeever, Agnes Lau, Janice Robertson
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Acta Neuropathologica Communications
Subjects:
Amyotrophic lateral sclerosis
Frontotemporal dementia
C9orf72
PSD-95
GluR1
Rab39b
Online Access:http://link.springer.com/article/10.1186/s40478-019-0812-5

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http://link.springer.com/article/10.1186/s40478-019-0812-5

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